Gordon W. Gribble

Gordon W. Gribble is a native of San Francisco, California, and completed his undergraduate education at the University of California at Berkeley in 1963. He earned a Ph.D. in organic chemistry at the University of Oregon in 1967. After a National Cancer Institute Postdoctoral Fellowship at the University of California, Los Angeles, he joined the faculty of Dartmouth College in 1968 where has been Full Professor of Chemistry since 1980. He served as Department Chair from 1988-1991. Professional awards include a National Institutes of Health Research Career Development Award, 1971-76, a National Science Foundation Science Faculty Professional Development Award, 1977-78, and the American Cyanamid Academic Award in 1988. He won the Dartmouth Distinguished Teaching Award in 1997, and in 1998 was awarded the Chemistry Alumni Award by the University of Oregon. In 2005, he was named to the newly endowed Chair as "The Dartmouth Professor of Chemistry," and in 2006 won the Arts and Sciences Graduate Faculty Mentoring Award. Dr. Gribble has published 315 papers in natural product synthesis, synthetic methodology, heterocyclic chemistry, natural organohalogen compounds, and synthetic triterpenoids, one of which is currently in Phase 2 clinical trials for the treatment of melanoma and pancreatic cancer. Another group of compounds, "DNA Bis-Intercalators", shows promise against the brain tumor glioblastoma in mice. Since 1995 he has co-edited the annual series "Progress in Heterocyclic Chemistry", and the 2nd edition of "Palladium in Heterocyclic Chemistry", co-authored with Jack Li, was published last year. Dr. Gribble has had a long-standing interest in organic chemical toxicity, chemical carcinogenesis, chemicals in the environment, and naturally occurring organohalogen compounds, and he has just finished his second monograph on naturally occurring organohalogen compounds. As a home winemaker for the past 30 years, he has a strong interest in the chemistry of wine and winemaking.

Education:

A.A. 1961 San Francisco City College

B.S. 1963 University of California, Berkeley

Ph.D. 1967 University of Oregon

PROFESSIONAL POSITIONS:

1967-1968 Postdoctoral Fellow, University of California, Los Angeles

1968-1974 Assistant Professor of Chemistry, Dartmouth College

1974-1980 Associate Professor of Chemistry, Dartmouth College

1977-1978 Visiting Associate, California Institute of Technology

1980-         Professor of Chemistry, Dartmouth College

1988-1991 Chair, Department of Chemistry, Dartmouth College

1991-1992 Visiting Professor of Chemistry, University of Hawaii

1993-         Associate Member, Norris Cotton Cancer Center

1994-         Scientific Advisor, American Council on Science and Health

1995-         Co-Editor, Progress in Heterocyclic Chemistry

1997-         Member, European Science and Environment Forum

1998-2002 Member, American Chemical Society Norris Award Committee

1999-2000 Visiting Professor of Chemistry, University of California, Santa Cruz

2003-         Associate Editor, "Current Organic Chemistry"

2003-         Editorial Board Referee Chairman, "Arkivoc"

2006-2007 Research Fellow in Chemistry and Civil War Era Studies, Gettysburg College

Research BACKGROUND:

41 years of teaching experience, 315 research publications, 3 monographs

Awards:

1965-1967 National Institutes of Health Predoctoral Fellowship

1967-1968 National Cancer Institute Postdoctoral Fellowship

1971-1976 National Institutes of Health Research Career Development Award

1977-1978 National Science Foundation Professional Development Award

1981           Dartmouth College, Honorary Masters Degree

1984-1985 Dartmouth College, Senior Faculty Fellowship

1988           American Cyanamid Academic Award

1991-1992 Dartmouth College, Senior Faculty Fellowship

1997           Dartmouth College, Distinguished Teaching Award

1998           University of Oregon Chemistry Alumni Achievement Award

1999-2000 Dartmouth College, Senior Faculty Fellowship

2005           Named the first "Dartmouth Professor of Chemistry" at Dartmouth College

2006           Arts and Sciences Graduate Faculty Mentoring Award

Professional Societies:

American Chemical Society, International Society of Heterocyclic Chemistry, American Wine Society

CURRENT RESEARCH AREAS:

Synthesis of Biologically Active Natural Products, Heterocyclic Chemistry, Organic Synthetic

Methodology, New Indole Chemistry, Anticancer Drug Design, Chemopreventive Synthetic and Natural Triterpenoids, Natural Organohalogen Compounds, New Antimalarial Compounds

TEACHING AREAS:

Undergraduate organic chemistry, undergraduate environmental chemistry, graduate physical organic chemistry, graduate heterocycle chemistry

MENTORING AND SYNERGISTIC ACTIVITIES:

Total number of undergraduate researchers supervised: 125

Total number of graduate students directly supervised: 45

Total number of postdoctoral research associates: 29

Presented eight short courses on aspects of heterocyclic chemistry

Editorial column author on numerous societal and environmental issues related to chemistry.

REPRESENTATIVE RECENT PUBLICATIONS (of 314 total):

1. "Isolation and Structure Determination of the Cembranoid Eunicin from a New Genus of Octocoral, Pseudoplexaura"; Sponholtz, III, W.R.; Bianco, M.A.; Gribble, G.W. Nat. Prod. Res. 2008, 22, 441-448.

2. "One-Pot Synthesis of Pyrrolylamides and Pyrrolylimides by Tin- and Indium-Mediated Reductive Acylation of 2- and 3-Nitropyrroles"; Fu, L.; Gribble, G.W. Synthesis 2008, 788-794.

3. "Efficient Reductive Acylation of 3-Nitroindoles"; Roy, S.; Roy, S.; Gribble, G.W. Tetrahedron Lett. 2008, 49, 1531-1533.

4. "Synthesis of 1,2'- and 1,3'-Bipyrroles from 2- and 3-Nitropyrroles"; Fu, L.; Gribble, G.W. Tetrahedron Lett. 2008, 49, 3545-3548.

5. "The Rexinoid LG100268 and the Synthetic Triterpenoid CDDO-Methyl Amide Are More Potent than Erlotinib for Prevention of Mouse Lung Carcinogenesis "; Liby, K.; Black, C.C.; Royce, D.B.; Williams, C.R.; Risingsong, R.; Yore, M.M.; Liu, X.; Honda, T.; Gribble, G.W.; Lamph, W.W.; Sporn, T.A.; Dmitrovsky, E.; Sporn, M.B. Mol. Cancer Ther. 2008, 7, 1251-1257.

6. "Prevention and Treatment of Experimental Estrogen Receptor-Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268"; Liby, K.; Risingsong, R.; Royce, D.B.; Williams, C.R.; Yore, M.M.; Honda, T.; Gribble, G W.; Lamph, W.W.; Vannini, N.; Sogno, I.; Albini, A.; Sporn, M.B. Clin. Cancer Res. 2008, 14, 4556-4563.

7. "Mn(III)-Based Radical Addition Reactions of 2-Nitroindole with Activated CH Compounds"; Androsov, D.A.; Kishbaugh, T.L.S.; Gribble, G.W. Tetrahedron Lett. 2008, 49, 6621-6623.

8. "A Simple Synthesis of 2,2'-Bipyrroles from Pyrrole"; Fu, L.; Gribble, G.W. Tetrahedron Lett. 2008, 49, 7352-7354.

9. "A Short Synthesis of the Naturally Occurring Heptachloro- (Q1) and Heptabromo-1’-methyl-1,2'-bipyrroles"; Fu, L.; Gribble, G.W. Org. Prep. Proc. Int. 2008, 40, 561-566.

10. "Structure and Biosynthesis of Halogenated Alkaloids"; Gribble, G.W., In Modern Alkaloids - Structure, Isolation, Synthesis and Biology; Fattorusso, E; Taglialatela-Scafati, O., Eds.; Wiley-VCH: Weinheim, Germany, 2008, 591-618.