Gordon W. Gribble
Bio:
Gordon W. Gribble is a native of San Francisco, California, and completed his undergraduate education at the University of California at Berkeley in 1963. He earned a Ph.D. in organic chemistry at the University of Oregon in 1967. After a National Cancer Institute Postdoctoral Fellowship at the University of California, Los Angeles, he joined the faculty of Dartmouth College in 1968 where has been Full Professor of Chemistry since 1980. He served as Department Chair from 1988-1991. Professional awards include a National Institutes of Health Research Career Development Award, 1971-76, a National Science Foundation Science Faculty Professional Development Award, 1977-78, and the American Cyanamid Academic Award in 1988. He won the Dartmouth Distinguished Teaching Award in 1997, and in 1998 was awarded the Chemistry Alumni Award by the University of Oregon. In 2005, he was named to the newly endowed Chair as “The Dartmouth Professor of Chemistry,” and in 2006 won the Arts and Sciences Graduate Faculty Mentoring Award. Dr. Gribble has published 315 papers in natural product synthesis, synthetic methodology, heterocyclic chemistry, natural organohalogen compounds, and synthetic triterpenoids, one of which is currently in Phase 2 clinical trials for the treatment of melanoma and pancreatic cancer. Another group of compounds, "DNA Bis-Intercalators", shows promise against the brain tumor glioblastoma in mice. Since 1995 he has co-edited the annual series “Progress in Heterocyclic Chemistry”, and the 2nd edition of “Palladium in Heterocyclic Chemistry”, co-authored with Jack Li, was published last year. Dr. Gribble has had a long-standing interest in organic chemical toxicity, chemical carcinogenesis, chemicals in the environment, and naturally occurring organohalogen compounds, and he has just finished his second monograph on naturally occurring organohalogen compounds. As a home winemaker for the past 30 years, he has a strong interest in the chemistry of wine and winemaking.
Education: A.A. 1961 San
Francisco City College B.S.
1963 University of California, Berkeley Ph.D. 1967 University
of Oregon PROFESSIONAL POSITIONS: 1967-1968 Postdoctoral
Fellow, University of California, Los Angeles 1968-1974 Assistant
Professor of Chemistry, Dartmouth College 1974-1980 Associate
Professor of Chemistry, Dartmouth College 1977-1978 Visiting
Associate, California Institute of Technology 1980- Professor
of Chemistry, Dartmouth College 1988-1991 Chair,
Department of Chemistry, Dartmouth College 1991-1992 Visiting
Professor of Chemistry, University of Hawaii 1993- Associate
Member, Norris Cotton Cancer Center 1994- Scientific
Advisor, American Council on Science and Health 1995- Co-Editor,
Progress in Heterocyclic Chemistry 1997- Member,
European Science and Environment Forum 1998-2002 Member,
American Chemical Society Norris Award Committee 1999-2000 Visiting
Professor of Chemistry, University of California, Santa Cruz 2003- Associate
Editor, “Current Organic Chemistry” 2003- Editorial
Board Referee Chairman, “Arkivoc” 2006-2007 Research Fellow in
Chemistry and Civil War Era Studies, Gettysburg College Research BACKGROUND: 41 years of teaching experience,
315 research publications, 3 monographs Awards: 1965-1967 National Institutes
of Health Predoctoral Fellowship 1967-1968 National Cancer Institute
Postdoctoral Fellowship 1971-1976 National Institutes
of Health Research Career Development Award 1977-1978 National Science Foundation
Professional Development Award 1981 Dartmouth College, Honorary
Masters Degree 1984-1985 Dartmouth College,
Senior Faculty Fellowship 1988 American Cyanamid Academic
Award 1991-1992 Dartmouth College,
Senior Faculty Fellowship 1997 Dartmouth College, Distinguished
Teaching Award 1998 University of Oregon Chemistry
Alumni Achievement Award 1999-2000 Dartmouth College,
Senior Faculty Fellowship 2005 Named the first "Dartmouth
Professor of Chemistry" at Dartmouth College 2006 Arts and Sciences Graduate
Faculty Mentoring Award Professional Societies: American Chemical Society,
International Society of Heterocyclic Chemistry, American Wine Society CURRENT RESEARCH AREAS: Synthesis of Biologically Active
Natural Products, Heterocyclic Chemistry, Organic Synthetic Methodology, New Indole Chemistry,
Anticancer Drug Design, Chemopreventive Synthetic and Natural Triterpenoids,
Natural Organohalogen Compounds, New Antimalarial Compounds TEACHING AREAS: Undergraduate organic chemistry,
undergraduate environmental chemistry, graduate physical organic chemistry,
graduate heterocycle chemistry MENTORING AND SYNERGISTIC
ACTIVITIES: Total number of undergraduate
researchers supervised: 125 Total number of graduate students
directly supervised: 45 Total number of postdoctoral
research associates: 29 Presented eight short courses
on aspects of heterocyclic chemistry Editorial column author on
numerous societal and environmental issues related to chemistry. REPRESENTATIVE RECENT
PUBLICATIONS (of 314 total): 1. "Isolation and Structure
Determination of the Cembranoid Eunicin from a New Genus of Octocoral,
Pseudoplexaura"; Sponholtz, III, W.R.; Bianco, M.A.; Gribble,
G.W. Nat. Prod. Res. 2008, 22, 441-448. 2. "One-Pot Synthesis
of Pyrrolylamides and Pyrrolylimides by Tin- and Indium-Mediated Reductive
Acylation of 2- and 3-Nitropyrroles"; Fu, L.; Gribble, G.W.
Synthesis 2008, 788-794. 3. "Efficient Reductive
Acylation of 3-Nitroindoles"; Roy, S.; Roy, S.; Gribble, G.W.
Tetrahedron Lett. 2008, 49, 1531-1533. 4. "Synthesis of 1,2’-
and 1,3’-Bipyrroles from 2- and 3-Nitropyrroles"; Fu, L.; Gribble,
G.W. Tetrahedron Lett. 2008, 49, 3545-3548. 5. "The Rexinoid LG100268
and the Synthetic Triterpenoid CDDO-Methyl Amide Are More Potent than
Erlotinib for Prevention of Mouse Lung Carcinogenesis
"; Liby, K.; Black, C.C.; Royce, D.B.; Williams, C.R.; Risingsong,
R.; Yore, M.M.; Liu, X.; Honda, T.; Gribble, G.W.; Lamph, W.W.; Sporn,
T.A.; Dmitrovsky, E.; Sporn, M.B. Mol. Cancer Ther. 2008,
7, 1251-1257. 6. “Prevention and Treatment
of Experimental Estrogen Receptor-Negative Mammary Carcinogenesis by
the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268”;
Liby, K.; Risingsong, R.; Royce, D.B.; Williams, C.R.; Yore, M.M.; Honda,
T.; Gribble, G W.; Lamph, W.W.; Vannini, N.; Sogno, I.; Albini, A.;
Sporn, M.B. Clin. Cancer Res. 2008, 14, 4556-4563. 7. "Mn(III)-Based Radical
Addition Reactions of 2-Nitroindole with Activated CH Compounds";
Androsov, D.A.; Kishbaugh, T.L.S.; Gribble, G.W. Tetrahedron Lett.
2008, 49, 6621-6623. 8. "A Simple Synthesis
of 2,2’-Bipyrroles from Pyrrole"; Fu, L.; Gribble, G.W. Tetrahedron
Lett. 2008, 49, 7352-7354. 9. "A Short Synthesis
of the Naturally Occurring Heptachloro- (Q1) and Heptabromo-1’-methyl-1,2’- 10. "Structure and Biosynthesis
of Halogenated Alkaloids"; Gribble, G.W., In Modern Alkaloids
– Structure, Isolation, Synthesis and Biology; Fattorusso, E;
Taglialatela-Scafati, O., Eds.; Wiley-VCH: Weinheim, Germany, 2008,
591-618.